23 drug efflux one of the most studied mechanisms of cancer drug resistance involves reducing drug accumulation by enhancing efflux members of the atp binding cassette abc transporter family proteins enable this efflux and are important well studied regulators at the plasma membranes of healthy cells. Drug resistance in cancer cells cancer cells can acquire resistance to chemotherapy by a range of mechanisms including the mutation or overexpression of the drug target inactivation of the drug . Cancer cells can adapt and develop resistance to chemotherapy drugs making it difficult to eradicate tumors a new study led by investigators from brigham and womens hospital suggests that a . Duesberg p stindl r hehlmann r explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy
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